Vytautas Smirnovas
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Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives. Šneideris T, Baranauskienė L, Cannon JG, Rutkienė R, Meškys R, Smirnovas V. PeerJ 2015;3: e1271. doi:10.7717/peerj.1271

pH-Driven Polymorphism of Insulin Amyloid-Like Fibrils. Sneideris T, Darguzis D, Botyriute A, Grigaliunas M, Winter R, Smirnovas V. PLoS One 2015;10: e0136602. doi:10.1371/journal.pone.0136602

Polymorphism of amyloid-like fibrils can be defined by the concentration of seeds. Sneideris T, Milto K, Smirnovas V. PeerJ 2015;3: e1207. doi:10.7717/peerj.1207

Flavone derivatives as inhibitors of insulin amyloid-like fibril formation. Malisauskas R, Botyriute A, Cannon JG, Smirnovas V. PLoS One 2015;10: e0121231. doi:10.1371/journal.pone.0121231

Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX. Dudutienė V, Matulienė J, Smirnov A, Timm DD, Zubrienė A, Baranauskienė L, et al. Journal of Medicinal Chemistry 2014;57: 9435–9446. doi:10.1021/jm501003k

Elongation of mouse prion protein amyloid-like fibrils: Effect of temperature and denaturant concentration. Milto K, Michailova K, Smirnovas V. PLoS One 2014;9: e94469. doi:10.1371/journal.pone.0094469

Conformational stability of mammalian prion protein amyloid fibrils is dictated by a packing polymorphism within the core region. Cobb NJ, Apostol MI, Chen S, Smirnovas V, Surewicz WK. Journal of Biological Chemistry 2014;289: 2643–2650. doi:10.1074/jbc.M113.520718

Amyloid-Like Fibril Elongation Follows Michaelis-Menten Kinetics. Milto K, Botyriute A, Smirnovas V. PLoS One 2013;8: e68684. doi:10.1371/journal.pone.0068684

Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Smirnovas V, Baron GS, Offerdahl DK, Raymond GJ, Caughey B, Surewicz WK. Nature Structural and Molecular Biology 2011;18: 504–506. doi:10.1038/nsmb.2035

Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. Smirnovas V, Kim J Il, Lu X, Atarashi R, Caughey B, Surewicz WK. Journal of Biological Chemistry 2009;284: 24233–24241. doi:10.1074/jbc.M109.036558

Islet amyloid polypeptide and high hydrostatic pressure: towards an understanding of the fibrillization process. Lopes DHJ, Smirnovas V, Winter R. Journal of Physics Conference Series 2008;121: 112002. doi:10.1088/1742-6596/121/11/112002

Copolymer microgels from mono- And disubstituted acrylamides: Phase behavior and hydrogen bonds. Keerl M, Smirnovas V, Winter R, Richtering W. Macromolecules 2008;41: 6830–6836. doi:10.1021/ma800785w

Interplay between hydrogen bonding and macromolecular architecture leading to unusual phase behavior in thermosensitive microgels. Keerl M, Smirnovas V, Winter R, Richtering W. Angewandte Chemie - International Edition 2008;47: 338–341. doi:10.1002/anie.200703728

Revealing different aggregation pathways of amyloidogenic proteins by ultrasound velocimetry. Smirnovas V, Winter R. Biophysical Journal 2008;94: 3241–3246. doi:10.1529/biophysj.107.123133

Effect of pressure on islet amyloid polypeptide aggregation: Revealing the polymorphic nature of the fibrillation process. Radovan D, Smirnovas V, Winter R. Biochemistry 2008;47: 6352–6360. doi:10.1021/bi800503j

Cytotoxicity of Insulin within its Self-assembly and Amyloidogenic Pathways. Grudzielanek S, Velkova A, Shukla A, Smirnovas V, Tatarek-Nossol M, Rehage H, et al. Journal of Molecular Biology 2007;370: 372–384. doi:10.1016/j.jmb.2007.04.053

Effects of lipid confinement on insulin stability and amyloid formation. Kraineva J, Smirnovas V, Winter R. Langmuir 2007;23: 7118–7126. doi:10.1021/la700405y

The effects of various membrane physical-chemical properties on the aggregation kinetics of insulin. Grudzielanek S, Smirnovas V, Winter R. Chemistry and Physics of Lipids 2007;149: 28–39. doi:10.1016/j.chemphyslip.2007.05.006

Solvation-assisted pressure tuning of insulin fibrillation: From novel aggregation pathways to biotechnological applications. Grudzielanek S, Smirnovas V, Winter R. Journal of Molecular Biology 2006;356: 497–509. doi:10.1016/j.jmb.2005.11.075

Protein amyloidogenesis in the context of volume fluctuations: A case study on insulin. Smirnovas V, Winter R, Funck T, Dzwolak W. ChemPhysChem 2006;7: 1046–1049. doi:10.1002/cphc.200500717

New insights into the self-assembly of insulin amyloid fibrils: An H-D exchange FT-IR study. Dzwolak W, Loksztejn A, Smirnovas V. Biochemistry 2006;45: 8143–8151. doi:10.1021/bi060341a

Template-controlled conformational patterns of insulin fibrillar self-assembly reflect history of solvation of the amyloid nuclei. Dzwolak W, Jansen R, Smirnovas V, Loksztejn A, Porowski S, Winter R. Physical Chemistry Chemical Physics 2005;7: 1349–1351. doi:10.1039/b502255j

A conformational alpha-helix to beta-sheet transition accompanies racemic self-assembly of polylysine: An FT-IR spectroscopic study. Dzwolak W, Smirnovas V. Biophysical Chemistry 2005;115: 49–54. doi:10.1016/j.bpc.2005.01.003

Ethanol-perturbed amyloidogenic self-assembly of insulin: Looking for origins of amyloid strains. Dzwolak W, Grudzielanek S, Smirnovas V, Ravindra R, Nicolini C, Jansen R, et al. Biochemistry 2005;44: 8948–8958. doi:10.1021/bi050281t

Thermodynamic properties underlying the α-helix-to-β-sheet transition, aggregation, and amyloidogenesis of polylysine as probed by calorimetry, densimetry, and ultrasound velocimetry. Smirnovas V, Winter R, Funck T, Dzwolak W. Journal of Physical Chemistry B 2005;109: 19043–19045. doi:10.1021/jp053283w

Insulin forms amyloid in a strain-dependent manner: an FT-IR spectroscopic study. Dzwolak W, Smirnovas V, Jansen R, Winter R. Protein Science 2004;13: 1927–1932. doi:10.1110/ps.03607204

Determination of the dissociation constant and stoichiometry of a complex of the protein interferon alpha-2b with cibacron blue F3G-A. Bumeliene Z, Sereikaite I, Bumelis V A, Smirnovas V, Gedminiene G, Braziunaite L, et al. Journal of Analytical Chemistry 2003;58: 1038–1041. doi:10.1023/A:1027325120597

Synthesis of new SAM-forming ferrocene derivatives and their interfacial properties on gold. Kažemėkaitė M, Bulovas A, Smirnovas V, Niaura G, Butkus E, Razumas V. Tetrahedron Letters 2001;42: 7691–7694. doi:10.1016/S0040-4039(01)01625-2

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